High-level exposure to methylmercury is known as Minamata disease. Acute Toxicity: Dermal: 108-88-3 (Toluene) LD50 Rabbit: 12,124 mg/kg Oral: 108-88-3 (Toluene) LD50 Rat: 5000mg/kg Inhalation: 108-88-3 (Toluene) LC50 Rat: 12,500 - 28,800 mg/m3/4 h Chronic Toxicity: No additional information. The Forensic Aspects of Poisons . If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. The exposure may also be through direct skin and eye contact, or upon inhaling the vapors; This intake could be accidental, or in some cases intentional, to bring self-harm; Toluene is a poisonous liquid that is highly flammable ; Note: The … Identification . OSHA Table Z-1-A (29 CFR 1910.1000), as amended TWA 100 ppm 375 mg/m3 US. The data to date are inadequate to draw conclusions regarding whether immunosuppression may be a more sensitive endpoint (i.e., an endpoint that would result in a lower point of departure) than kidney toxicity. CONC 500 ppm US. It has also been suggested that the toxicity of toluene may be due to some of its metabolic intermediates. Acute toxicity (Dermal) - Category 4. The key difference between benzene and toluene is their structure; toluene has a methyl group attached to the benzene ring while benzene has no methyl groups attached.. Benzene and Toluene are two aromatic compounds having a slight difference between them in their structure. They are mild mucous membrane irritants that affect the eyes and the respiratory and GI tracts. 11,13,15,16 Absorption occurs from inhalation, ingestion, or transdermal exposure, and can be detected in blood within minutes. White matter T2 hyperintensity (focal and diffuse) is the most common finding, seen in approximately 50% of patients, typically after at least 4 years of abuse. Specific target organ toxicity - Single exposure - Category 1B. Toluene: health effects, incident management and toxicology Information on toluene, for use in responding to chemical incidents. It deprives cells of the ability to use oxygen. The odour threshold varies considerably; a geometric mean of 11 ppm has been estimated from published data (2). Toluene and xylene poisoning can occur when someone swallows these substances, breathes in their fumes, or when these substances touch the skin. The public should also … Toluene-3,4-dithiol | C7H8S2 | CID 10334 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Toluene is a hydrophobic solvent found in paint thinners, cleaning agents, adhesives, and gasoline, 11,12,14-16 and is the most commonly abused volatile substance worldwide, owing to its euphoric effects. Toluene TWA 20 ppm US. 108-88-3) In Support of Summary Information on the Integrated Risk Information System (IRIS) September 2005 U.S. Environmental Protection Agency Washington D.C. DISCLAIMER This document has been reviewed in accordance with U. S. Environmental Protection Agency policy and approved for publication. SCCP agrees that important official reports have been issued recently on the toxicity profile and safety of toluene, and has considered the following (summary) documents: 3.1.1. This structural difference has led to various differences in their reactivity and usage. A volatile petrochemical solvent and paint thinner, toluene is a potent neurotoxicant that acts as an irritant, impairs breathing, and causes nausea. They may include muscle weakness, poor coordination, numbness in the hands and feet, skin rashes, anxiety, memory problems, trouble speaking, trouble hearing, or trouble seeing. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Low to moderate daily workplace exposure can cause temporary tiredness, confusion, weakness, nausea and memory loss. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . Symptoms depend upon the type, dose, method, and duration of exposure. Like other aromatic hydrocarbons, they may sensitize the myocardium to the arrythmogenic effects of catecholamines. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. IN cases of suspected arsenic exposure it is imperative to call 911 for immediate transfer to the nearest hospital. Laboratory testing for acute toluene toxicity is hampered by the fact that blood tests for toluene and urinary tests for hippuric acid are not available in most hospitals. Health supervision visits forced to be viewed as business of a continuum of circumspection, not as the exploit of isolated tasks. The key to managing cyanide toxicity is patient education. OSHA Table Z-1-A (29 CFR 1910.1000), as amended MAX. Toluene Toxicity; Toluol Poisoning; What are the Causes of Toluene Poisoning? BACKGROUND AND PURPOSE: Chronic abuse of toluene by inhalation causes variable white matter changes and thalamic hypointensity on T2-weighted MR images. Respiratory sensitization - Category 2A-2B. Background: Toluene is one of the most widely abused inhaled drugs due to its acute neurologic effects including euphoria and subsequent depression. As a leading supplier of high-purity solvents, we have the right toluene to meet your needs. Chapter 5.14 Toluene General description Physical and chemical properties Toluene (C 6H 5CH 3) is a noncorrosive, volatile liquid with an aromatic odour. Other pertinent literature is also presented, but is described in less detail than the key studies. Toluene is a clear and colorless liquid that turns to vapor when exposed to air at room temperature. 77, No. Organ system toxicity: Dysfunction of the central nervous system following acute, intermediate or high inhalation exposure to toluene is a critical health concern. Long-term exposure can result in thickening of the skin, darker skin, abdominal pain, diarrhea, heart disease, numbness, and cancer. Whether you need HPLC toluene, ACS toluene, anhydrous toluene or one of the other grades available, we offer the right product for your application. Toluene, the main component of volatile glues, lacquer thinners and aerosol paints is the chemical responsible for most clinical toxicity. This article is for information only. F igure 3.2. It has been suggested that toluene interferes with the normal function of neuronal proteins. Female reproductive toxicity endpoint removed from listing for toluene effective March 7, 2014. MRI is the modality of choice for evaluation of cerebral changes related to toluene toxicity. This can be accomplished by chemotaxis. Toluene, or toluol as it was once called, is the simplest aromatic hydrocarbon except for benzene. Mechanism of toxicity. for metabolites been ascertained in the toxicity of toluene. Toluene Safety Data Sheet according to Federal Register / Vol. Its solubility in water is 535 mg/litre (1). Public Notices Related to this Chemical. Corrosion Irritation: Dermal: 108-88-3 (Toluene) Rabbit: Skin Irritation - 24 h Sensitization: No additional information. The bodies of cult members of the People’s Temple, in. Classic symptoms of arsine gas toxicity include headache, nausea, vomiting, diarrhea, "port wine" hued urine and jaundice. Pulmonary aspiration may cause a hydrocarbon pneumonitis (See Hydrocarbons). DO NOT use it to treat or manage an actual poison exposure. Toluene and xylene cause generalized CNS depression. The toxicity of cyanide is due to its ability to stop cellular respiration and ATP (adenosine triphosphate, a source of cel- lular energy) synthesis in cells, causing what is called cytotoxic or metabolic anoxia . ACGIH Threshold Limit Values, as amended STEL 150 ppm 560 mg/m3 US. 1.1. Environmental influences. Product form : Substance Substance name : Toluene CAS-No. Acute toxicity (Inhalation: Dusts and mists) - Category 2. Toluene Poisoning is caused by the ingestion of toluene (liquid). TOLUENE (CAS No. CNS toxicity may be due to the liposolubility of toluene in the neuronal membrane. When exposure to toluene occurs there is usually simultaneous exposure to several other chemicals. It is lethal at low doses, and affected individuals may not notice the toxicity until hours after exposure. 28. Four years later, French chemist Henri Étienne Sainte-Claire Deville isolated it from “tolu balsam” (extracted from the Colombian tree Myroxylon balsamum). Skin corrosion/irritation - Category 4. Mention of trade names or commercial products does not constitute … COVID-19 is an emerging, rapidly evolving situation. Cyanide can even be absorbed through the skin, hence people who work with cyanide-related chemicals must wear appropriate garments and protective inhalational devices. Toxicity refers to the other BTEX compounds come into close physical contact with pollutants neurologic effects euphoria.: toluene CAS-No other BTEX compounds, `` port wine '' hued urine and jaundice that the until. 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